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Literature summary extracted from

  • Shi, L.; Sun, L.; Li, Q.; Liang, J.; Yu, W.; Yi, X.; Yang, X.; Li, Y.; Han, X.; Zhang, Y.; Xuan, C.; Yao, Z.; Shang, Y.
    Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis (2011), Proc. Natl. Acad. Sci. USA, 108, 7541-7546 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.11.67 additional information Homo sapiens the enzyme is physically associated with the MLL2 complex in vivo ?
-
-
1.14.11.67 [histone H3]-N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2 Homo sapiens
-
 [histone H3]-N6,N6-dimethyl-L-lysine4 + succinate + formaldehyde + CO2
-
 ?
1.14.11.67 [histone H3]-N6,N6,N6-trimethyl-L-lysine9 + 2-oxoglutarate + O2 Homo sapiens
-
 [histone H3]-N6,N6-dimethyl-L-lysine9 + succinate + formaldehyde + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.11.67 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.14.11.67 anti-FLAG immunoaffinity resin column chromatography Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.11.67 MCF-7 cell
-
 Homo sapiens
-
1.14.11.67 MDA-MB-231 cell
-
 Homo sapiens
-
1.14.11.67 ZR-75-1 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.11.67 additional information the enzyme is physically associated with the MLL2 complex in vivo Homo sapiens ?
-
-
1.14.11.67 [histone H3]-N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2
-
 Homo sapiens [histone H3]-N6,N6-dimethyl-L-lysine4 + succinate + formaldehyde + CO2
-
 ?
1.14.11.67 [histone H3]-N6,N6,N6-trimethyl-L-lysine9 + 2-oxoglutarate + O2
-
 Homo sapiens [histone H3]-N6,N6-dimethyl-L-lysine9 + succinate + formaldehyde + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.11.67 H3K9 trimethyl demethylase
-
 Homo sapiens
1.14.11.67 JMJD2B
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
1.14.11.67 malfunction enzyme depletion impairs the estrogen-induced G1/S transition of the cell cycle in vitro and inhibits breast tumorigenesis in vivo Homo sapiens
1.14.11.67 physiological function the enzyme promotes cell proliferation of breast cancer in vitro and tumorigenesis in vivo. The enzyme functions as a demethylase in estrogen signaling. The enzyme is transcriptionally regulated by estrogen receptor alpha. Through the up-regulation of the enzyme, estrogen receptor alpha and the enzyme form a feedforward regulatory loop to enhance and amplify the hormone response under physiological as well as pathological conditions Homo sapiens